在exon 2的上游插入了loxP位点,通过同源重组,又在exon 3的下游插入了FRT标记的neo cassette和另一个loxP位点。通过Flp介导的重组,neo cassette被移除,使得exons 2和3被留下了loxP标记。(来源:J:330965)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count