Ptpn22^tm1.1Hlmdl

Cysteine codon 129 (TGT) in exon 5 was changed to serine (TCC) (p.C129S) and a loxP site, tACE-Cre (Cre gene driven by the testis-specific angiotensin I converting enzyme gene promoter), a neomycin resistance gene cassette and a second loxP site were inserted into intron 5. The neo cassette was self-excised through testis-expressed Cre-mediated recombination. The mutation leads to reduced catalytic activity of the encoded peptide. (J:342728)