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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Fgfr1
tm15.1Sor
Alias:
Fgfr1
FCPGMyc
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基础信息
表型特征
文献报道
通过对小鼠Fgfr1基因进行同源重组,插入了5个点突变:第8外显子的L423A和V429A,第9外显子的Y463F,第17外显子的Y766F和Y776F。在基因的最后一个外显子末尾,放置了一个2xMyc的内切标签。通过Cre介导的重组,去除了第8外显子带有loxP序列的诺卡因 cassette。(来源:J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
7575769
129S4/SvJaeSor
Targeted
Insertion, Nucleotide substitutions
--
1
25
--
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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