编码肽中第265位的 cysteine (C) 被替换为 serine (S)(p.C265S),并在基因下游插入了含 FRT 和 loxP 突变位点的诺卡因抗性基因元件。随后通过 Flp 介导的重组移除了这个 neo cassette。这个突变阻止了该氨基酸残基的 S-硝基化(来源:J:342739)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
Insertion, Single point
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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