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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
转基因模型
Tg(Gpa33-rtTAS*M2)2Lud
Alias:
BAC(A33:M2rtTA)
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基础信息
表型特征
文献报道
M2rtTA这种转录激活器在肠道和结肠的上皮细胞中,通过特异性的A33启动子进行表达。转激活器的表达和活性是镶嵌的,这可能是由于随机的转基因沉默导致。在近端小肠大约1到5个隐窝会表达这个转录因子,而在远端的肠道和结肠中则较少(来源:J:104190)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
7569264
129 x C57BL/6
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Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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