Etv6^em3Knic

Arginine codon 355 (CGA) in exon 6 was changed to a stop codon (TGA) (p.R355*) using an sgRNA and an ssODN template with CRISP/Cas9 technology. The mutation is the equivalent of the human p.R359* mutation associated with thrombocytopenia 5 (T5). (J:342774)