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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Mstn
em2(Gdf11)Rlee
Alias:
Gdf8
11MD
Gdf8
Gdf11MD
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基础信息
表型特征
文献报道
使用CRISPR/Cas9技术,通过sgRNAs和dsODN模板,将exon 3中编码成熟区域(从二酸基268到丝氨酸376)的序列替换为同源基因Gdf11(从天冬氨酸297到丝氨酸405)的等效序列。(来源:J:342779)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
7568819
C57BL/6J
Endonuclease-mediated
插入,基因内删除
--
1
2
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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