使用CRISPR/Cas9技术,通过sgRNAs和dsODN模板,将exon 3中编码成熟区域(从二酸基268到丝氨酸376)的序列替换为同源基因Gdf11(从天冬氨酸297到丝氨酸405)的等效序列。(来源:J:342779)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
插入,基因内删除
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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