Umod^em1Ymc

CRISPR/Cas9 technology generated a 27-bp deletion, Y178 to R186, in exon 3. This is equivalent to the human p.His177-Arg185 del in-frame deletion, one of the most prevalent mutations in autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD). (J:343282)