在小鼠染色体7上,一个30kb的缺失区域从Apoe到Apoc被人类染色体19(HSA19)上的一个47kb同源区域替换。这个替换涉及了小鼠的Apoe(apoE)基因4型和Apoc(apolipoprotein C)基因,被人类的APOE(等位基因E4)和APOC基因所取代。构建中包含了一个loxP位点的诺卡因抗性基因 cassette。通过Cre短暂表达,这个诺卡因 cassette被去除了(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NTac
Targeted
Insertion, Intergenic deletion
--
4
--
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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