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中文
CRISPR/Cas9导向的基因组编辑通过在exon 4创建一个12个碱基对的缺失来实现，这个突变移除了KRKR的编码序列。使用了两个导向RNA(5'-ccagcctcaggaagcg gaaa-3'和5'-cggaatccagcctcaggaag-3')，Cas9内切酶，以及一个120个核苷酸的修复模板。这个删除影响了硫酸肝素的结合，但不影响IFNGR的结合。(来源：J:335280)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
