靶向载体设计为在第3外显子上游插入一个loxP位点,接着是FRT框包裹的PGK-neomycin元件,再后面是第4外显子上游的另一个loxP位点。通过Flp介导的重组移除了neo cassette,随后Cre介导的重组去除了第3外显子。(来源:J:257103)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
基因间区删除
--
1
10
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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