在CRISPR/Cas9技术中,第10个内含子被设计了两个sgRNAs靶向,导致了268bp的缺失(参考GRCm39:chr17:27178158-27178425)。这个缺失去除了NMD(核糖体沉默)调控下使用的3'剪接接受体位点。(来源:J:334714)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Endonuclease-mediated
基因内删除
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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