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中文
在exon 15的第481位， cysteine(CTG)被替换成了serine(ACC)，变异表现为p.C481S，这是通过sgRNA和ssODN模板，利用CRISPR/Cas9技术实现的。这种改变使得编码的多肽对B细胞增殖和生存抑制剂ibrutinib失去敏感性。(引用：J:340979)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
