这个BAC克隆包含了整个Lum基因,利用了Lum基因的内源性起始密码子来驱动CreERT2的表达。Exon 2的编码序列以及2号外显子和内含子2之间的剪接起始点(50bp)被替换成了包含CreERT2开放阅读框和Lum基因3'非翻译区(UTR)的 cassette。在Lum的3'UTR中插入了人生长激素(hGHpA)的polyadenylation信号。来源:(J:342042)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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