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中文
在exon 15的arginine(685位点)被替换为alanine(685位点的阿尔法)使用了一条crRNA(针对AAGGTTTAGGGACACTTACTCGG)和ssODN模板，通过CRISPR/Cas9技术。这个突变消除了PTP1B的结合，进而导致NTRK1的去磷酸化。(来源：J:338830)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
