Itpr1^tm1.1Swch

A GAC to AAA change resulting in an aspartate to lysine substitution at amino acid 2594 (p.D2594K) was introduced in the channels gating domain. The inserted FRT-flanked neomycin selection cassette was removed via flp-mediated recombination. This mutation increases the sensitivity of IP3-induced calcium release and is a gain-of-function allele. (J:341866)