在Mib1基因的内含子中插入了以下内容:一个loxP位点、抗氨苄青霉素抗性基因、一个终止子 cassette,另一个loxP位点,一段编码野生型Mib1蛋白内有的HA标签的序列,插入了间隔序列(IRES)以及绿色荧光蛋白(EGFP)报告基因。只有在Cre介导去除neo-STOP cassette后,插入的Mib1和EGFP基因才会表达。(来源:J:338889)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
插入
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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