CRISPR/cas9 mediated recombination using guide RNA (GGTGGTCAGCTGACCATTGA) and donor vector (ACCATGGAGATGGAAGGCAGTGGTGGTCAGCTGACCATTGATCGCAGCATCCTGGCTGCAGTTGGCAACTTCATCGTAGTC) induced a G to C mutations resulting in a G to R substitution at position 2298 in exon 40. (J:341698)