Slc39a8^tm1.1Brvo

Alanine codon 393 (GCT) in exon 7 was changed to threonine (ACT) (p.A393T) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation is the equivalent of the human p.A391T mutation (SNP rs13107325) associated with numerous traits, including reduced arterial blood pressure, increased body mass index and hyperlipidemia. (J:341571)