Tg(tetO-APPSwInd, KRT14-EGFP)#Dbo

The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2.The transgene was co-integrated with a transgene in which the human KRT14 (K14) promoter drives skin-specific expression of EGFP. (J:340366)