Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo

The mouse amyloid beta (A4) precursor protein (App) sequence was first modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (called mo/huAPP695 or APP695) was further mutated to incorporate the Swedish (K595M/N596L) mutation associated with Alzheimer's disease. This APP695Swe/Ind sequence was placed downstream of the brain-specific mouse prion promoter (Prnp). The first transgene was co-integrated with a second transgene in which the mouse prion promoter promoter drives expression of a mutant human presenilin 1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease. (J:340366)