这个靶向构建在exon 4的上游插入了loxP位点,下游跟着一个由FRT引导的诺卡因抗性基因座,基因座带有3'的loxP标记,然后是突变的exon 4,去除了3'端的UTR。通过FLP介导的重组移除了选择性基因座,留下exon 4的野生型形式被loxP序列标记。随后,Cre介导的重组会去除exon 4。(来源:J:284194)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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