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中文
在exon 4的arginine(AGG)位置被替换成了leucine(CTT)，编码序列变为p.R80L，这是通过sgRNAs(针对GAGGAGGATAAAGCCCGAAG和TGACTCACAGCAAGTCTGGG)和ssODN模板，利用CRISPR/Cas9技术实现的。R80对于matriptase介导的编码肽切割是必需的，参考文献为J:340720。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
