Exons 6 of the Cabin1 gene is floxed. Flp-mediated recombination removed the selection marker. After Cre-mediated recombination. Deletion of exon 6 will result in the loss of function of the Cabin1 gene by generating a frameshift from exon 5 to exons 7-12 (premature Stop codon in exon 8). (J:101977)