Kozak-Cre-pA cassette通过同源重组在ES细胞中替换了murine Tmem233基因的起始密码子ATG。通过Dre介导的重组后,带有rox标记的Neo cassette被去除了,这形成了一个无功能性等位基因。(来源:J:340699)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count