在内皮1中插入了含耐药性基因FRT和终止子的序列。第2外显子(exon 2,首个编码外显子)的Gly12位置被替换为Cysteine(GCT),编码为p.G12C。这种等位基因只有在通过Flp介导移除neo-STOP cassette后才会表达。这种变异等同于肺癌中发现的人类相同突变(J:334559)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
Insertion, Single point
--
1
37
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部