包含在尼氏体2特异性域中阿尔法氨基酸替换,保持结构氨基酸不变,以及带有FRT座的羟氨苄青霉素 cassette的磁带,通过重组酶介导的 cassette exchange在含有Nkx2-2tm1Suss的ES细胞中插入。随后,通过Flp介导的重组移除了羟氨苄青霉素 cassette。(来源:J:338878)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
核苷酸替换
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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