Ube3a^em1Mjz

Threonine codon 503 (ACT) in exon 6 was changed to alanine (GCA) (NP_001380595.1:p.T503A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation is the equivalent of the human NP_570853.1:p.T485A gain-of-function mutation associated with autism when expressed from the paternal allele. (J:338299)