4号外显子和5号外显子由loxP序列包被,5号内含子中插入了由frt标记包裹的阳性选择标记( puromycin抗性),随后通过FLP介导的重组在生殖细胞中去除。随后在生殖细胞中通过Cre介导的重组,导致了4号和5号外显子的删除。(来源:J:268644)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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