这个靶向载体通过同源重组在胚胎干细胞中将CAG启动子、FRT和3XpA介导的、LoxP和3XpA标记的tdTomato-p2A-DreO、以及Neo插入到了Gt(ROSA)26Sor基因中。要表达tdTomato和DreO重组酶,需要通过Flp和Cre重组酶去除这两个STOP序列。(来源:J:338445)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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