在第7外显子的Thr283位置,使用sgRNA(靶向GCTAGAGCCCCGGGGGGCTT)和ssODN模板,通过CRISPR/Cas9技术,其编码肽的PEST区域的改变,即人类B细胞非霍奇金淋巴瘤(B-NHL)相关突变,将可被磷酸化的氨基酸替换为磷酸阻断剂,并使肽的稳定性增强。(来源:J:304765)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Endonuclease-mediated
单点
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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