将iCre重组酶基因,由小鼠Acrv1启动子序列驱动,并带有hygromycin抗性基因座,两侧带有翻转子识别靶位点的cDNA插入到Gt(ROSA)26Sor定位序列中。经生殖传递后,这些小鼠与Flp剔除线杂交,以去除hygromycin抗性基因座。(来源:J:338406)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count