捐赠者通过体内同源重组技术,在小鼠的3F2.1和3F2.2染色体上构建了含有0.8兆碱基的重复或缺失,这些区域与人类的1q21.1区域具有同源性。简而言之,他们在基因组中插入了loxP位点,以环绕目标的复制/删除区域,随后由Cre酶介导的重组移除了插入序列。(来源:J:94077)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count