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中文
在exon 5的第187位，苯丙氨酸的密码子(TTT)被替换成了甘氨酸(GGC)，这导致了一个名为p.F187G的突变。通过sgRNA(靶向ACTCCTGATGGATGCGCTTA)和ssODN模板，应用了CRISPR/Cas9技术。这个改变使得编码的肽失去催化活性，不再具备RNA甲基化功能。(引用：J:314427)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
