Adar^em1Crwy

Proline codon 195 (CCT) in exon 2 was changed to alanine (GCT) (p.P195A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation is the equivalent of the human p.P193A mutation associated with AicardiGoutieres Syndrome (AGS). (J:338600)