A flippase recombinase target (FRT)-flanked region containing the LacZ beta-Galactosidase and Neomycin expression genes and a LoxP-flanked region containing exons 4 and 5 was inserted into the gene. The targeting vectors PRPGS00171_A_H03 used to generate Nrf2-knockout mice were purchased from the International Knockout Mouse Consortium (project KOMP-CSD 298710). (J:240623)