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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Lyn
em2Fret
Alias:
LynB
KO
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基础信息
表型特征
文献报道
CRISPR/cas9通过一个针对LynB同源剪接位点(exon 2的插入位点)的单个引导RNA,进行的重组引入了两个单核苷酸变异,消除了这个剪接位点(J:338556)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
7513895
C57BL/6J
Endonuclease-mediated
核苷酸替换
--
1
1
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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