Ank2^em1Melr

CRISPR/Cas9 technology generated a GAA to GGC change resulting in a glutamic acid to glycine substitution at amino acid 1371 (p.E1371G) in the spectrin-binding domain. Multiple silent coding changes were also introduced to block the Cas9 targets. This corresponds to the human p.E1458G variant associated with arrhythmias and structural remodeling. (J:338515)