CRISPR/Cas9基因编辑技术用于产生了exon 2的缺失。 hippocampal和 cerebellar组织的 Western blot分析确认了纯合突变小鼠中蛋白质表达的缺失(来源:J:338143)。
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CRISPR/Cas9 genome editing technology was used to generate a deletion of exon 2. Western blot analysis of hippocampal and cerebellar lysates confirmed the absence of protein expression in homozygous mutant mice. (J:338143)