这个等位基因是在表型基因组学中心通过电穿孔方式,用带有AGCGTGTGCTATGTCGATGC和TGACCCATATCCGGGCACAT这两条特定引物的Cas9核糖核酸蛋白复合体,针对染色体8的5'端和3'端的某个关键区域进行的。这导致了8号染色体上1128个碱基的缺失,位置从76,351,357到76,352,484(GRCm39),产生了移码并引入了早闭合终止密码子。(来源:J:265051)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
不确定
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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