CRISPR/cas9基因编辑用来去除Exon 6。Intron 5的sgRNA(Runx1E6_gRNA.254,GGGCACCGAGTCCCAGACTG)设计针对Mouse(Mus musculus)的mm10基因组测序坐标92644590至92644609,而Intron 6的sgRNA(Runx1E6_gRNA.121,GAAACCCCGCAGCATCAGCT)则针对位置92644031至92644050的Chr 16。参考文献:J:265272
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count