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中文
这个等位基因是在小鼠基因座中通过RMCE在TT2衍生的ES细胞克隆71-5F2-23中通过未知的Igs54(整合位点)的靶向替换产生的。原始的ES细胞克隆整合了CAG-lox71-bsr-pA-lox511-FRT-lox2272的靶向lox序列。bsr基因通过Cre介导的重组被lox66-cre-pA-MC1neopA-lox2272表达载体替换，使得CAG启动子驱动Cre重组酶的表达。RMCE后，选择出了ES细胞克隆e，并产生了嵌合体，随后验证了遗传传递。(来源：J:243719)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
