在基因下游,通过CRISPR/Cas9技术针对包含Tbx5肺增强子Rr426和随后的CTCF结合序列Rr108735的区域进行了sgRNAs的靶向,实现了1950bp的缺失,位置在chr5:120239699-120241648(GRCm39)。(来源:J:335096)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count