在基因下游,通过CRISPR/Cas9技术针对包含Tbx5肺增强子Rr426和随后的CTCF结合序列Rr108735的区域进行了sgRNAs的靶向,实现了1950bp的缺失,位置在chr5:120239699-120241648(GRCm39)。(来源:J:335096)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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