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在Ctif和Zbtb7c之间的拓扑关联域(CTAD)边界区域，或者作为绝缘体存在的区域，它分隔了Smad7的CTAD和Smad2的CTAD，这个区域通过CRISPR/Cas9技术用sgRNAs(靶向TAAGATCTGTGCTACGGGGGGGG, CATCTGGCTAGCTCAATACACGG, CAATGGGATCTCCTTGGTCCTGG和CAAGCAGGGCAAGGGAGATTGGG)进行了修饰，导致了72070bp的缺失(染色体18:75847706-75919775，GRCm39)。(来源：J:335096)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
