在Tbx5和Rbm19之间的拓扑关联域(TEAD)边界区域,或者说是隔离Tbx5和Lhx5TEAD的绝缘体,通过CRISPR/Cas9技术用sgRNAs针对AGATCTAAGACAGCCATGACAGG、CACTTTAGTAAAGTGTTGGGTGG、TTACACACCAATAATTGGGGGGG和CATAGGATACAGATATGTTGAGG这些序列,实现了21118bp的删除,位置在chr5:120225179-120246296(参考GRCm39)。(来源:J:335096)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count