基于小鼠BAC RP23-318M13构建了靶向载体。在包含HS1-HS5(HS5-1)敏感性区域序列的序列下游插入了loxP位点。上游插入了由loxP位点引导的诺卡因抗性基因座。调节区域位于Pcdha基因簇下游,调控其基因的表达。(来源:J:277249)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count