CRISPR/Cas9技术在exon 2产生了一个1bp插入,将AC替换为AAC,以沉默Swap70的表达。 Western blot结果显示心肌中没有检测到蛋白质(来源:J:335520)
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CRISPR/Cas9 technology generated a 1-bp insertion in exon 2, changing the 221 to 222 bases from AC into AAC to silence the expression of Swap70. Western blot analysis confirmed the absence of protein in heart. (J:335520)