通过sgRNA和ssODN模板,利用CRISPR/Cas9技术,Serine的第68位(AGC)被替换为Alanine(替换为GCT),这个变异(记为p.S68A)阻止了该高度保守的残基被MAPK通常磷酸化(来源:J:327336)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Applicable
Endonuclease-mediated
核苷酸替换
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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