这个等位基因是在表型遗传学中心通过电穿孔法产生了,使用了Cas9核糖核酸蛋白复合物,同时注射了带有间隔序列AAGAACTGTGGAGCTACGGC和GTATTGCTTCCAATCCGGCA的单导RNA,靶向的是ENSMUSE00000614088基因的内含子区域。这导致了12号染色体上919bp的缺失,位置从61,886,383到61,887,301(GRCm39),引入了frameshift和一个早止密码子。(来源:J:265051)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
不确定
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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