这个等位基因是通过CRISPR-Cas9导向,将连接了2A肽的creERT2 cDNA插入Dll4基因的终止密码子前,然后在R1小鼠胚胎干细胞中通过同源重组实现的纯合突变产生的。(来源:J:317975)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Endonuclease-mediated
插入
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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